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The Apothecary Diariesis finally back! Season 2 is one of Winter 2025’s most anticipated anime, promising romance and captivating medical mysteries. The success of Season 1 skyrocketed, pulling anime fans into the light novel series with its engaging characters, compelling protagonist, and intriguing mysteries.

The Apothecary Diariesis a historical mystery series centered on a young apothecary named Maomao. The anime steals the spotlight with its unique story and characters, where even beyond the central romance, the side characters have their own charm.
Amid the excitement forThe Apothecary DiariesSeason 2, the creditless opening animation has premiered on TOHO Animation’s YouTube channel, just hours before the anime’s highly anticipated debut. The Season 2 opening captures the charm of its predecessor but falls short of the widespread acclaim and global impact that Season 1’s opening achieved.

The Apothecary DiariesSeason 2 Opening struggles to match the brilliance of Season 1
Hailed by many as one of the most beautiful anime series of 2024,The Apothecary Diariesis based on the titular light novel series written by Natsu Hyuga and illustrated by Touko Shino. It began serialization in Shosetsuka ni Naro in 2011 and was later acquired by Shufunotomo.
Avid romance anime fans have gravitated towardThe Apothecary Diariesdue to the undeniable chemistry betweenJinshi and Maomao throughout theseries.

With the arrival of Season 2, the anime opening offers a glimpse into what lies ahead, hinting at deeper mysteries, compelling character development, and the continuation of the intrigue that made the first season so beloved.
4 Major Arcs The Apothecary Diaries Season 2 Opening Teases That Fans Aren’t Ready For
The Apothecary DiariesSeason 2 unveils its creditless opening theme, “Hyakka Ryoran (Splendid Bounty),” performed by Lilas Ikuta of YOASOBI.
As shared onThe Apothecary Diarieswebsite, Lilas Ikuta expressed her honor in performing the Season 2 opening after experiencing Season 1 firsthand.

While crafting the song, she aimed to infuse fresh energy into the anime, capturing the same excitement she feltwhen immersed in its storyand characters.
The Season 2 opening ofThe Apothecary Diariesis creating a buzz online, with fanspraising its captivating visuals and music.

However, it has yet to surpass the highly acclaimed Season 1 opening, which made waves globally, resonating with anime enthusiasts, and earning its place as one of the most beloved anime themes of the year.
The opening song “Hana ni Natte” by Ryokuoushoku Shakai served as the first theme forThe Apothecary Diariesanime, used from episodes 1 through 12. The song became a global sensation, transcending language barriers to capture the hearts of fans everywhere, becoming an unforgettable favorite.
Gaoshun: The most mysterious and intriguing side-character
Gaoshun is one of the older side characters, and he has a very paternal air to his personality. While Maomao and Jinshi’s romance plays a central role, Gaoshun emerges as one of the most intriguing characters, winning fans’hearts as the story unfolds.
Gaoshun often serves as the deadpan sounding board for Jinshi and Maomao. His exasperation with their anticsprovides plenty of humor, making him bothentertaining and an essential part of the story.
The Apothecary Diaries Season 2 Opening Hides a Big Secret About Maomao’s Feelings for Jinshi
While he is a supporting character, he’s actually a favorite of many fans for his serious but gentle demeanor.
The director ofThe Apothecary Diarieshascalled Gaoshun their favorite character, even over the main lead, highlighting his popularity. On the surface, Gaoshun seems calm, aloof, and capable, but beneath it all, he harbors a fear of women, stemming from his overly bossy wife and daughter, which adds to his character’s charm.
The Apothecary Diariesis available to stream on Crunchyroll
Mehul Rolta
Articles Published :510
Mehul Rolta is a seasoned journalist with over 3 years in esports and soccer journalism. Transitioning to anime writing at Fandom Wire, Mehul shares his lifelong passion for anime about integrates professionalism. Dedicated to connecting the world of anime globally, Mehul shares thoughts and insights, communicating personal passion with professional insight.